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How Redemplo® can help you reach a new
Redemplo uses a small piece of RNA, called , to reduce the amount of your liver makes. With less APOC3, your body can clear fat from your blood effectively.
People with Familial Chylomicronemia Syndrome (FCS) have extremely high (fat in the blood). This causes fat particles called chylomicrons to build up in the bloodstream, which can make the blood look milky or cloudy.
The liver creates a protein called , which slows the breakdown and removal of triglyceride-rich particles from the bloodstream. Reducing APOC3 production can lower triglycerides.
Redemplo uses a small piece of RNA, called , to reduce the amount of APOC3 your liver makes. With less APOC3, your body can clear fat from your blood effectively.
Redemplo has a targeting signal that is recognized only by the liver. This brings it inside liver cells, where APOC3 is made.
Inside the liver cell, Redemplo engages the RNA-induced silencing complex (RISC)—the machinery cells use to degrade specific mRNAs. mRNAs are the blueprints of proteins like APOC3.
Redemplo guides RISC to specifically degrade APOC3 mRNA, the blueprints that code for APOC3 protein. Without the instructions provided by the mRNA blueprints, the liver cell stops making APOC3 protein.
By lowering APOC3, Redemplo helps your body clear chylomicrons more effectively. When taken with a low-fat diet (less than or equal to 20 grams of fat per day), Redemplo lowers triglycerides in the blood. Redemplo is convenient, with just one dose every 3 months.
Click to see how Redemplo helps lower triglycerides from FCS.
Redemplo lowered APOC3 levels quickly and continuously
APOC3 Levels Dropped at Month 1 and Generally Stayed Low Through Month 10
By lowering APOC3 levels, Redemplo reduces triglycerides in adults with FCS when used in combination with a low-fat diet
APOC3, apolipoprotein C-III; FCS, Familial Chylomicronemia Syndrome; RNA, ribonucleic acid; siRNA, small interfering RNA.
Not an actual patient.
Convenient dosing with one injection every 3 months
Explore convenient dosingIndication & Important Safety Information
Indication
REDEMPLO® (plozasiran) is an injectable prescription medicine used together with a low-fat diet to reduce triglycerides (fat in the blood) in adults with a condition that keeps the body from breaking down fats called familial chylomicronemia syndrome (FCS).
Important Safety Information
Before you start using REDEMPLO, tell your healthcare provider about all your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if REDEMPLO could harm your unborn baby, or if it passes into your breast milk and could harm your breastfeeding baby.
Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.
What are the possible side effects of REDEMPLO?
The most common side effects of REDEMPLO include increased blood sugar levels, headache, nausea, and injection site reactions (pain, redness, or swelling).
These are not all the possible side effects of REDEMPLO. Tell your healthcare provider or treatment team if you have any side effect that bothers you or that does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.