How Redemplo^® can help you reach a new

People with Familial Chylomicronemia Syndrome (FCS) have extremely high triglyceridesTriglyceridesTriglycerides are a type of fat in your blood that your body uses for energy. They travel through the bloodstream in tiny particles called chylomicrons (from the food you eat). When these particles are not cleared properly, or when they carry too much fat, they can build up in the blood. (fat in the blood). This causes fat particles called chylomicrons to build up in the bloodstream, which can make the blood look milky or cloudy.

The liver creates a protein called apolipoprotein C-III (APOC3)Apolipoprotein C-III (APOC3)APOC3 is a protein that sticks to triglyceride-rich particles in the blood. Sometimes it helps to think of it as a “speed bump” that slows down how quickly the body can clear these fat particles. One way it does this is by blocking lipoprotein lipase (LPL), the enzyme that normally helps the body break down and clear triglycerides. APOC3 also prevents the removal of broken-down fat particles by the liver., which slows the breakdown and removal of triglyceride-rich particles from the bloodstream. Reducing APOC3 production can lower triglycerides.

Redemplo uses a small piece of RNA, called siRNAsiRNAsiRNA therapy targets messenger RNA (mRNA), which are the instruction sheets cells use to make proteins. The siRNA binds to a specific mRNA and marks it for destruction, so the cell can’t make that protein. Sometimes it helps to think of it like shredding a harmful blueprint so it can’t be used., to reduce the amount of APOC3 your liver makes. With less APOC3, your body can clear fat from your blood effectively.

Redemplo has a targeting signal that is recognized only by the liver. This brings it inside liver cells, where APOC3 is made.

Inside the liver cell, Redemplo engages the RNA-induced silencing complex (RISC)—the machinery cells use to degrade specific mRNAs. mRNAs are the blueprints of proteins like APOC3.

Redemplo guides RISC to specifically degrade APOC3 mRNA, the blueprints that code for APOC3 protein. Without the instructions provided by the mRNA blueprints, the liver cell stops making APOC3 protein.

By lowering APOC3, Redemplo helps your body clear chylomicrons more effectively. When taken with a low-fat diet (less than or equal to 20 grams of fat per day), Redemplo lowers triglycerides in the blood. Redemplo is convenient, with just one dose every 3 months.