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Understanding FCS and the risks
What is Familial Chylomicronemia Syndrome (FCS)?
FCS is an extreme type of severe hypertriglyceridemia (sHTG) that makes it hard for your body to break down and remove . People with FCS may have 10 to 100 times more triglycerides than normal in their blood, even with standard treatment and a strict low-fat diet (less than 20 grams of fat per day).
These high levels of triglycerides cause the blood to appear milky or cloudy and may lead to serious health problems like sudden and painful acute pancreatitis events, fatigue and physical weakness, and fatty lumps under the skin called eruptive xanthomas. People with FCS may also feel symptoms such as bloating, indigestion, nausea, abdominal pain, and vision changes.
Even with treatment, very high triglycerides and FCS can cause emotional and social burdens. With treatment and support, people living with FCS can find ways to feel more in control of their triglycerides.
Think you may have FCS?
If your triglycerides are 880 mg/dL or higher* and you have any of the following, you could have FCS.
Recurrent acute pancreatitis attacks
Hospitalizations for severe stomach pain without any reason
History of childhood pancreatitis
Family history of acute pancreatitis caused by HTG
Prior genetic confirmation of FCS
*In excess of 1000 mg/dL at least 3 times; does not respond well to lipid-lowering
therapy.
HTG, hypertriglyceridemia.
Patients with triglycerides >500 mg/dL face an increased risk of acute pancreatitis
DID YOU KNOW
that acute pancreatitis caused by high triglycerides is more serious than other causes of ? Even one event can increase the chance of another. Expert guidelines support lowering triglycerides below 500 mg/dL to reduce the risk of acute pancreatitis.
Are you at risk for acute pancreatitis?
Choose your triglyceride level to see how you could be impacted
ACUTE PANCREATITIS RISK
Retrospective cohort study annualized incidence rate of acute pancreatitis.
Data were
obtained from IQVIA’s US Ambulatory Electronic Medical Records database (N=7,119,195).
People with triglycerides over 500 mg/dL, like those with FCS, are in an acute pancreatitis risk danger zone.
Just one meal can spike your triglyceride levels
Triglycerides in the blood mostly come from the food you eat. FCS makes it difficult for your body to break down and remove triglycerides, causing levels to spike even after just one meal. This can greatly increase your risk for acute pancreatitis.
Regular triglyceride testing can help you stay in the know about your FCS
According to the American Association of Clinical Endocrinology, triglyceride testing every 3 months, or more frequently when necessary, can help monitor your triglyceride levels. This can be especially important when starting on a new treatment for your FCS.
See how Redemplo® can help you experience a new LO
Recognize the impact of Redemplo
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Convenient dosing with one injection every 3 months
Explore convenient dosingIndication & Important Safety Information
Indication
REDEMPLO® (plozasiran) is an injectable prescription medicine used together with a low-fat diet to reduce triglycerides (fat in the blood) in adults with a condition that keeps the body from breaking down fats called familial chylomicronemia syndrome (FCS).
Important Safety Information
Before you start using REDEMPLO, tell your healthcare provider about all your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if REDEMPLO could harm your unborn baby, or if it passes into your breast milk and could harm your breastfeeding baby.
Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.
What are the possible side effects of REDEMPLO?
The most common side effects of REDEMPLO include increased blood sugar levels, headache, nausea, and injection site reactions (pain, redness, or swelling).
These are not all the possible side effects of REDEMPLO. Tell your healthcare provider or treatment team if you have any side effect that bothers you or that does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.